Julie L. MacIsaac

This study examines DNA methylation in children from a Congo Basin community, linking it to family dynamics like parental conflict and father caregiving, and identifies associated biological pathways.

This study shows exercise induces methylome and transcriptome changes in skeletal muscle, independent of COPD and age, with some changes linked to inflammation and others to tissue remodeling.

RAMEN dissects gene-environment contributions to DNA methylome variability in cord blood, finding genetics explains the largest proportion of DNAme variance.

This study identifies DNA methylation sites in PBMCs associated with cumulative family adversity in children, suggesting PBMC DNAm as a marker for biological embedding of cumulative adversity.

The paper examines how genetic and environmental factors influence DNA methylation at variably methylated regions in neonatal blood, finding that combined effects best explain methylation variability.

The paper introduces a biologically informed polygenic score for insulin receptor-related genes in mesocorticolimbic regions and shows it better predicts childhood impulsivity and early addiction risk than conventional scores.