BLTP1-dependent phospholipid efflux prevents mitochondrial lipid overload and apoptosis at FKBP8-tethered ER-mitochondrial contact
Qingzhu Chu, Xinran Lu, Tiansi Cui, Zhaomin Zhou, Jun Luo, Weiping Chang, Lin Deng, Wei-Ke Ji
This study identifies BLTP1 as a mitochondrial phospholipid transporter that prevents lipid overload and apoptosis by exporting phospholipids via FKBP8-tethered ER-mitochondrial contacts.
bioRxiv · Sep 30, 2025 · PreprintCell Biology