Wei Yang

Programmable De Novo Design of Mesoporous Protein Crystal Frameworks

This paper presents a modular strategy to design programmable, highly porous protein crystals with tunable architectures and composition, enabling applications in catalysis and biomedicine.

MiRNA let-7a-5p Ameliorates Pulmonary Fibrosis by Suppressing TGFBR1-Mediated Endothelial-to-Mesenchymal Transition

This study identifies let-7a-5p as a suppressor of pulmonary fibrosis by inhibiting TGFBR1-mediated EndoMT in IPF patients.

Revisiting CPUs for Protein Folding: Xeon-Based Acceleration of AlphaFold2

This paper presents an optimized AlphaFold2 implementation for CPUs, achieving significant speedups and higher throughput compared to GPU-based solutions.

MLL3 and MLL4 sustain hematopoietic stem cell multipotency by opposing a B-cell default state

This study shows that MLL3 and MLL4 maintain hematopoietic stem cell multipotency by opposing a B-cell default state through distinct enhancer regulation mechanisms.

Functional Comparison to Ezh2 Reveals PRC2-Independent Functions of Jarid2 in Hematopoietic Stem Cell Lineage Commitment

The paper compares the roles of Jarid2 and Ezh2 in hematopoiesis, finding Jarid2 has PRC2-independent functions affecting lineage commitment.

Mutation of phosphatidate phosphohydrolase genes confers broad-spectrum disease resistance in plants

The paper shows that mutating phosphatidate phosphohydrolase (PAH) genes in rice and Arabidopsis increases phosphatidic acid (PA) levels and broad-spectrum disease resistance.

Genomic and transcriptomic analyses of the elite rice variety Huizhan provide insight into disease resistance and heat tolerance

This study presents a chromosome-scale genome assembly of the rice variety Huizhan and identifies gene families and genes associated with disease resistance and heat tolerance.

Neural signals encoded by specific frequencies of closed-loop electrical stimulation structurally and functionally reconstruct spinal sensorimotor circuits after spinal cord injury

This study identifies 10-20 Hz closed-loop electrical stimulation as critical for structural and functional reconstruction of spinal sensorimotor circuits after SCI.

Microbial Cells Harboring a Mitochondrial Gene Are Capable of CO2 Capture

This study identifies a mitochondrial gene, OG1, capable of CO2 capture in engineered microorganisms, suggesting its potential for mitigating global warming through biological CO2 capture in barren lands.

De novo transcriptomic characterization of Betta splendens for identifying sex-biased genes potentially involved in aggressive behavior modulation and EST-SSR maker development

This study performs de novo transcriptomic analysis of Betta splendens to identify sex-biased genes related to aggressive behavior and develop EST-SSR markers.

Clinically Important sex differences in GBM biology revealed by analysis of male and female imaging, transcriptome and survival data

The paper identifies sex-specific molecular subtypes of glioblastoma and shows that temozolomide is more effective in female patients, suggesting sex-specific treatment approaches could improve outcomes.

The anatomical distribution of genetic associations

The paper develops a framework to test the relationship between gene expression across the body and sets of candidate genes, applying it to GWA loci, immune traits, and selective pressure in human genes.