GeneticsHuman Molecular GeneticsPeer-reviewed
Werner syndrome helicase modulates G4 DNA-dependent transcription and opposes mechanistically distinct senescence-associated gene expression programs
Weiliang Tang, Ana I. Robles, Richard P. Beyer…·Raymond J. Monnat
This study examines mRNA and miRNA expression changes in Werner syndrome patient fibroblasts and WRN-depleted cells, revealing WRN's role in modulating G4 DNA-dependent transcription and distinct senescence-associated gene programs.
DOI 10.1093/hmg/ddw079