Junwen Wang

Juvenile AAV-Mediated MEF2C Gene Replacement Ameliorates Selected Phenotypes in Mef2c-Haploinsufficient Mice

This study shows that juvenile AAV-mediated MEF2C gene replacement can improve specific phenotypes in Mef2c-haploinsufficient mice.

Multi-model biological and sequence information fusion for gene regulatory network inference from single-cell transcriptomics

This paper introduces scMGFGRN, a deep learning framework for gene regulatory network inference from single-cell transcriptomics, which outperforms existing methods by integrating multimodal biological data.

Rtel1 in hypothalamic oxytocin neurons regulates oxytocin output and social behaviors in mice

This study shows that Rtel1 in oxytocin neurons regulates oxytocin output and social behaviors in mice by resolving G-quadruplexes near the Oxt promoter.

Integrative Multi-Omics Analysis Identifies a Functional Enhancer Driving Tumorigenesis in Head and Neck Squamous Cell Carcinoma

The paper identifies a functional enhancer, GH05J001312, that drives tumorigenesis in HNSCC by enhancing TERT expression and affecting cancer-related pathways.

scDILT: a model-based and constrained deep learning framework for single-cell Data Integration, Label Transferring, and clustering

scDILT integrates single-cell datasets while preserving reference clustering patterns and mapping new cells to annotated clusters, outperforming existing methods on simulated and real data.