An evolving cancer instigates clonally unrelated neighboring cells to form distant metastases.
Jie Dong, Cedric Darini, Farhia Kabeer, Sarah Dendievel, Junxia Min, Dolores Hambardzumyan, Louis Gaboury, Tom Lenaerts, Guillaume Darrasse-Jèze, Yi Li, Katrina Podsypanina
This study shows that genetically unrelated cells can be induced by cancer cells to form metastases, challenging the clonal evolution theory of cancer progression.
bioRxiv · Nov 3, 2016 · PreprintCancer Biology