Author

Tom Lenaerts

Interuniversity Institute of Bioinformatics in BrusselsPrimary ORCID profile (0000-0003-3645-1455 · 4 papers)Unclaimed ORCID profile · follow to get notified of new preprints

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Same name, identified by ORCID

Tom LenaertsiD4 papers · Université Libre de Bruxelles

Biology Disciplines

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Bioinformatics· 1 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:benchmarking· 1 Research Focus:cancer & tumor microenvironment· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Organism:mouse· 1 Approach:statistical model· 1 Research Focus:variant effect prediction· 1 Assay:whole-exome sequencing· 1

Frequent Co-Authors

Ali Saadat· 1 shared Cedric Darini· 1 shared Cedric Van Marcke· 1 shared Dolores Hambardzumyan· 1 shared Eleonore Pairet· 1 shared Farhia Kabeer· 1 shared Guillaume Darrasse-Jèze· 1 shared Guillaume Smits· 1 shared

Activity by Year

2016-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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1 shared paperBioinformatics

Ali Saadat

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Author profile →

2 papers

Recent·Most cited

DoAggregate: a pipeline for aggregation testing for rare-variant on a gene and pathway level

Simon Boutry, Cedric Van Marcke, Nisha Limaye, Guillaume Smits, Pascal Pascal Brouillard, Martina De Bortoli, Eleonore Pairet, Ali Saadat, Raphael Helaers, Jacques Fellay, Tom Lenaerts, Miikka Vikkula

DoAggregate performs rare-variant aggregation tests across genes, pathways, and GO terms, providing detailed cohort-level results and visualizations.

bioRxiv · Nov 3, 2026 · PreprintBioinformatics

An evolving cancer instigates clonally unrelated neighboring cells to form distant metastases.

Jie Dong, Cedric Darini, Farhia Kabeer, Sarah Dendievel, Junxia Min, Dolores Hambardzumyan, Louis Gaboury, Tom Lenaerts, Guillaume Darrasse-Jèze, Yi Li, Katrina Podsypanina

This study shows that genetically unrelated cells can be induced by cancer cells to form metastases, challenging the clonal evolution theory of cancer progression.

bioRxiv · Nov 3, 2016 · PreprintCancer Biology