Yi Li

Evolution-Guided Engineering of Non-conserved N-Glycosylation Sites Improves Heterologous Production of Sulfotransferases

This paper introduces EGO-NGly, a method to improve heterologous production of sulfotransferases in E. coli by engineering non-conserved N-glycosylation sites, resulting in enhanced residual activity stability.

Dynamic architecture of the Rixosome reveals mechanism of activation and ITS2 processing

The paper presents cryo-EM structures of the Rixosome and pre-60S particles to elucidate the dynamic architecture and activation mechanism of the Rixosome for ITS2 processing.

K2P Channels Regulate Presynaptic Organisation through a Membrane Potential-Independent Mechanism

This study identifies a membrane potential-independent role for the K2P channel TWK-40 in regulating presynaptic organisation through intracellular potassium levels and interactions with PYK-1 and transcription factors.

Circadian clock gates retinal regeneration by orchestrating Cxcl12-dependent immune coordination

This study shows that the circadian clock regulates zebrafish retinal regeneration by controlling immune coordination via the Cxcl12-Cxcr4 axis.

Leveraging large language models for metabolic engineering design

This paper develops a large language model-based method to extract metabolic engineering strategies from research articles and trains a hybrid model to predict engineering targets, outperforming traditional approaches.

Clinical and Taxonomic Characterization of a Novel Urinary Tract Pathogen Providencia lanzhouensis

This paper identifies a novel Providencia species, Providencia lanzhouensis, from a urinary tract infection isolate using genomic and biochemical analyses.

Actomyosin-II Proactively Shields Axons of the Central Nervous System from Mild Mechanical Stress

The paper identifies actomyosin-II-driven radial contractility as a mechanism protecting central axons from mild mechanical stress and shows its protective role in a traumatic brain injury model.

Image processing and analysis methods for the Adolescent Brain Cognitive Development Study

The paper describes neuroimaging processing methods for the ABCD Study to extract brain phenotypes from multimodal imaging data.

CXCR4 involvement in neurodegenerative diseases

The paper identifies a genetic variant near CXCR4 associated with increased risk for PSP and PD, showing dysregulation of CXCR4 and microglia-related genes in neurodegenerative diseases.

An evolving cancer instigates clonally unrelated neighboring cells to form distant metastases.

This study shows that genetically unrelated cells can be induced by cancer cells to form metastases, challenging the clonal evolution theory of cancer progression.

Gene expression inference with deep learning

This paper introduces a deep learning method to infer gene expression from landmark genes, showing significant improvements over linear regression in multiple datasets.