Molecular BiologybioRxivPreprint
Structural and Dynamic Basis of TREM2--DAP12 Stabilization by Small-Molecule Agonist VG-3927
Fanyu Zhao, Wei Xia, Xintai Zhang…·John Z.H. Zhang
This study investigates how the small-molecule agonist VG-3927 stabilizes the TREM2-DAP12 complex by binding within a transmembrane cavity and altering its conformation.
DOI 10.64898/2026.06.22.732806