Author

Justin R. Sysol

University of Rochester Medicine

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Cell Biology· 1

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Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Approach:experimental assay· 1 Organism:human· 1

Frequent Co-Authors

Aaron Snow· 1 shared Amanda Jo Fisher· 1 shared Angelia D. LockettiD· 1 shared Manas Yadav· 1 shared Marta Teixeira Gomes· 1 shared Micheala A. AldrediD· 1 shared Pontian Adogamhe· 1 shared Roberto F. MachadoiD· 1 shared

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2025-2025 · peak 1/yr

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1 shared paperCell Biology

Aaron Snow

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1 paper

Recent·Most cited

Cell BiologybioRxivPreprintJun 10, 2025

The mitochondrial unfolded protein response and metabolic reprogramming promote PASMC proliferation in response to sphingosine kinase-1/sphingosine-1-phosphate signaling

Angelia D. Lockett, Aaron Snow, Pontian Adogamhe…·Roberto F. Machado

This study shows that the Sphk1/S1P/S1P2 signaling axis promotes PASMC proliferation in PAH via activation of the mitochondrial unfolded protein response (UPRmt), which can be inhibited to reduce vascular remodeling.

4 citations

humanbulk RNA-seq

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