Persistent vulnerability to heroin relapse across the adult lifespan in rats
Rajtarun Madangopal, Olivia R. Drake, Diana Q. Pham, Veronica A. Lennon, Sophia J. Weber, Justine Lee, Adekemi Sobukunola, Ava R. Holmes, Omodolapo Nurudeen, Yavin Shaham, Bruce T. Hope
This study shows that heroin relapse triggered by drug cues persists for over a year in abstinent rats, indicating long-term vulnerability to opioid relapse.
bioRxiv · Mar 20, 2026 · PreprintAnimal Behavior & Cognition