BioinformaticsmAbsPeer-reviewed
AbDesign: Database of point mutants of antibodies with associated structures reveals poor generalization of binding predictions from machine learning models.
Bartosz Janusz, Dawid Chomicz, Samuel Demharter…·Konrad Krawczyk
The paper creates a dataset of antibody-antigen complexes with mutations and evaluates affinity prediction methods, finding that current models poorly predict binding effects compared to empirical methods.
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