Molecular Mechanism of Action of Mitochondrial Therapeutic SS-31 (Elamipretide): Membrane Interactions and Effects on Surface Electrostatics
W. Mitchell, E. A. Ng, J. D. Tamucci, K. Boyd, M. Sathappa, A. Coscia, M. Pan, X. Han, N. A. Eddy, E. R. May, H. H. Szeto, N. N. Alder
This paper investigates how SS-31 interacts with mitochondrial membranes, showing it modulates surface electrostatics and lipid packing, supporting its mitoprotective mechanism.
bioRxiv · Aug 14, 2019 · PreprintBiophysics