M. Sathappa

Identification of Small Molecule Inhibitors of PPM1D Using a Novel Drug Discovery Platform

This study identifies new PPM1D inhibitors using a drug discovery platform and shows their distinct biological effects compared to other DDR and p53 pathway modulators.

Multimodal small-molecule screening for human prion protein binders

This study screens for small-molecule binders of the human prion protein using multiple methods but finds only a weak binder with no therapeutic potential.

Molecular Mechanism of Action of Mitochondrial Therapeutic SS-31 (Elamipretide): Membrane Interactions and Effects on Surface Electrostatics

This paper investigates how SS-31 interacts with mitochondrial membranes, showing it modulates surface electrostatics and lipid packing, supporting its mitoprotective mechanism.