Author

W. Mitchell

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 2 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Approach:biophysical modeling· 1 Research Focus:drug response / drug discovery· 1 Research Focus:metabolism & bioenergetics· 1 Assay:metabolomics· 1 Organism:yeast· 1

Frequent Co-Authors

N. N. Alder· 3 shared E. R. May· 2 shared H. H. Szeto· 2 shared A. Alexandrescu· 1 shared A. Coscia· 1 shared A. J. Rua· 1 shared A. T. Alexandrescu· 1 shared E. A. Ng· 1 shared

Activity by Year

2019-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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3 shared papersBiophysics

N. N. Alder

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Author profile →

3 papers

Recent·Most cited

Perturbations in mitochondrial metabolism associated with defective cardiolipin biosynthesis: An in-organello real-time NMR study

A. J. Rua, W. Mitchell, S. M. Claypool, N. N. Alder, A. T. Alexandrescu

This study uses in-organello NMR to analyze how cardiolipin defects affect mitochondrial metabolism in yeast, showing altered metabolite kinetics and TCA cycle flux.

bioRxiv · Jun 18, 2024Biophysics

Structure-Activity Relationships in the Design of Mitochondria-Targeted Peptide Therapeutics

W. Mitchell, J. Tamucci, E. Ng, S. Liu, H. H. Szeto, E. R. May, A. Alexandrescu, N. N. Alder

This study analyzes structure-activity relationships of mitochondria-targeted tetrapeptides, finding that side chain composition and sequence register significantly affect their efficacy and membrane interactions.

bioRxiv · Nov 8, 2021 · PreprintBiochemistry

Molecular Mechanism of Action of Mitochondrial Therapeutic SS-31 (Elamipretide): Membrane Interactions and Effects on Surface Electrostatics

W. Mitchell, E. A. Ng, J. D. Tamucci, K. Boyd, M. Sathappa, A. Coscia, M. Pan, X. Han, N. A. Eddy, E. R. May, H. H. Szeto, N. N. Alder

This paper investigates how SS-31 interacts with mitochondrial membranes, showing it modulates surface electrostatics and lipid packing, supporting its mitoprotective mechanism.

bioRxiv · Aug 14, 2019 · PreprintBiophysics