Author

K. Brehm

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 1 Microbiology· 1 Pharmacology & Toxicology· 1 Zoology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:drug response / drug discovery· 2 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Assay:proteomics· 2 Organism:E. coli· 1 Organism:mouse· 1 Approach:statistical model· 1

Frequent Co-Authors

A. Hemphill· 1 shared A. Koike· 1 shared A. Varcasia· 1 shared B. Lundström-Stadelmann· 1 shared C. Dissous· 1 shared C. Tamponi· 1 shared F. Becker· 1 shared J. K. Nono· 1 shared

Activity by Year

2018-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 12 mutual co-author links

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1 shared paperPharmacology & Toxicology

A. Hemphill

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Author profile →

4 papers

Recent·Most cited

Establishment and application of unbiased in vitro drug screening assays for the identification of compounds against Echinococcus granulosus s.s.

M. Kaethner, M. Preza, T. Kaempfer, P. Zumstein, C. Tamponi, A. Varcasia, A. Hemphill, K. Brehm, B. Lundström-Stadelmann

The paper establishes in vitro culture and drug screening assays for E. granulosus s.s., showing that MMV665807, niclosamide, and nitazoxanide are effective against both E. multilocularis and E. granulosus s.s.

bioRxiv · May 2, 2023 · PreprintPharmacology & Toxicology

Targeting Echinococcus multilocularis PIM kinase for improving anti-parasitic chemotherapy

A. Koike, F. Becker, P. Sennhenn, J. Kim, J. Zhang, S. Hannus, K. Brehm

This paper identifies EmPIM as a target for anti-AE chemotherapy and demonstrates that in silico-designed compounds can inhibit parasite growth with reduced toxicity to human cells.

bioRxiv · May 12, 2022Microbiology

A secreted Echinococcus multilocularis activin A homologue promotes regulatory T cell expansion

J. K. Nono, M. Lutz, K. Brehm

This paper identifies an Echinococcus multilocularis activin A homologue that promotes regulatory T cell expansion through TGF-β and IL-10 mechanisms.

bioRxiv · Apr 24, 2019 · PreprintImmunology

The role of fibroblast growth factor signalling in Echinococcus multilocularis development and host-parasite interaction

S. Förster, U. Koziol, T. Schäfer, R. Duvoisin, K. Cailliau, M. Vanderstraete, C. Dissous, K. Brehm

This study shows that human fibroblast growth factors (FGFs) activate Echinococcus multilocularis FGF receptors, supporting parasite development and suggesting FGF signaling as a drug target for alveolar echinococcosis.

bioRxiv · Oct 30, 2018Zoology