K. Campellone

Autophagosome turnover requires Arp2/3 complex-mediated maintenance of lysosomal integrity

This study shows that the Arp2/3 complex is essential for lysosomal integrity during autophagy, as its absence leads to lysosomal damage and impaired autophagic flux.

WHAMM functions in kidney reabsorption and polymerizes actin to promote autophagosomal membrane closure and cargo sequestration

This study shows WHAMM is essential for kidney reabsorption and autophagosome membrane closure by polymerizing actin, with loss of WHAMM causing albuminuria and autophagy defects.

F-actin-rich territories coordinate apoptosome assembly and caspase activation during intrinsic apoptosis

WHIMP links the actin nucleation machinery to Src-family kinase signaling during protrusion and motility

This paper identifies WHIMP as a new WASP-family protein that enhances cell motility through actin assembly and activates Src-family kinases, modulating WASP-family protein activation during protrusion.