BiochemistryJournal of Molecular BiologyPeer-reviewed
Structural Basis of Protein Arginine Methyltransferase Activation by a Catalytically Dead Homolog (Prozyme)
H. Hashimoto, L. Kafkova, A. Raczkowski…·E. W. Debler
This paper reports the crystal structure of a Trypanosoma brucei PRMT1 enzyme-prozyme heterotetramer, revealing how the prozyme stabilizes the enzyme and enables catalysis through structural and functional interactions.
DOI 10.1016/j.jmb.2019.11.002