Targeted therapy for LIMD1-deficient non-small cell lung cancer subtypes.
K. Davidson, P. Grevitt, M. Contreras, K. S. Bridge, M. Hermida, K. M. Shah, F. K. Mardakheh, M. Stubbs, P. A. Clarke, R. Burke, P. Casado-Izquierdo, P. R. Cutillas, S. A. Martin, T. V. Sharp
This paper identifies PF-477736 as a selective cytotoxic compound for LIMD1-deficient NSCLC cells and xenograft models, offering a potential targeted therapy for this understudied cancer subtype.
bioRxiv · Feb 1, 2021Cancer Biology