R. Burke

The polyamines spermine and spermidine inhibit or induce programmed cell death in Arabidopsis thaliana in vitro and in vivo in a dose dependent manner.

This study shows that spermine and spermidine regulate programmed cell death in Arabidopsis in a dose-dependent manner, acting as either inhibitors or inducers.

Transcriptional signatures associated with waterlogging stress responses and aerenchyma formation in barley root tissue

This study identifies transcriptional signatures and candidate genes associated with waterlogging stress responses and aerenchyma formation in barley roots.

Arabidopsis cell suspension culture and RNA sequencing reveal regulatory networks underlying plant programmed cell death.

The paper uses RNA sequencing of Arabidopsis suspension cells to identify gene regulatory networks and key transcriptional regulators involved in plant programmed cell death and stress responses.

CD4+ T cell lymphopenia and dysfunction in severe COVID-19 disease is autocrine TNF-α/TNFRI-dependent

The paper shows that autocrine TNF-α/TNFRI signaling drives CD4+ T cell lymphopenia and dysfunction in severe COVID-19, and TNF-α blockade improves outcomes.

Nutrient copper signaling promotes protein turnover by allosteric activation of ubiquitin E2D conjugases

This paper shows that copper signaling modulates protein turnover by allosterically activating ubiquitin E2D conjugases, linking copper levels to protein degradation and morphogenesis.

Targeted therapy for LIMD1-deficient non-small cell lung cancer subtypes.

This paper identifies PF-477736 as a selective cytotoxic compound for LIMD1-deficient NSCLC cells and xenograft models, offering a potential targeted therapy for this understudied cancer subtype.

Exploiting evolutionary herding to control drug resistance in cancer

This paper demonstrates evolutionary herding in non-small cell lung cancer to control drug resistance by shifting clonal composition and inducing collateral sensitivity.