Author

K. E. Moeder

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Biophysics· 1

Signature Assays, Organisms & Methods

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Approach:deep learning· 2 Research Focus:protein folding & dynamics· 2 Assay:protein structure· 2 Research Focus:cell type annotation· 1 Research Focus:clustering· 1 Research Focus:protein structure prediction· 1 Approach:statistical model· 1

Frequent Co-Authors

G. R. Bowman· 2 shared J. R. Porter· 2 shared M. I. Zimmerman· 2 shared C. A. Sibbald· 1 shared G. K. Amarasinghe· 1 shared K. M. Hart· 1 shared M. A. Cruz· 1 shared M. J. Greenberg· 1 shared

Activity by Year

2018-2020 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersBiochemistry

G. R. Bowman

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Author profile →

2 papers

Recent·Most cited

A cryptic pocket in Ebola VP35 allosterically controls RNA binding

M. A. Cruz, T. E. Frederick, U. L. Mallimadugula, S. Singh, N. Vithani, M. I. Zimmerman, J. R. Porter, K. E. Moeder, G. K. Amarasinghe, G. R. Bowman

This study identifies a cryptic pocket in Ebola VP35 that allosterically controls RNA binding, validated through simulations, experiments, and drug-like modifications.

bioRxiv · Feb 9, 2020Biochemistry

Cooperative changes in solvent exposure identify cryptic pockets, conformational switches, and allosteric coupling

J. R. Porter, K. E. Moeder, C. A. Sibbald, M. I. Zimmerman, K. M. Hart, M. J. Greenberg, G. R. Bowman

The paper introduces a method to identify functionally-relevant conformational changes in proteins by analyzing cooperative solvent exposure changes, demonstrating its utility in discovering cryptic allosteric sites.

bioRxiv · Sep 18, 2018Biophysics