Cold temperature induces a TRPM8-independent calcium release from the endoplasmic reticulum in human platelets
A. Stratiievska, O. Filippova, T. Ozpolat, D. Byrne, S. L. Bailey, M. Y. Mollica, J. Harris, K. Esancy, J. Chen, A. Dhaka, N. J. Sniadecki, J. A. Lopez, M. Stolla
This study shows cold temperature activates human platelets via TRPM8-dependent and -independent mechanisms, with TRPM8 involved in early activation and ER calcium release driving later responses.
bioRxiv · Jul 19, 2023 · PreprintCell Biology