J. Harris

Transmission bottleneck size estimation from de novo viral genetic variation

This paper estimates transmission bottleneck sizes using de novo viral genetic variation in recipients, finding tight bottlenecks for influenza A and SARS-CoV-2.

Cold temperature induces a TRPM8-independent calcium release from the endoplasmic reticulum in human platelets

This study shows cold temperature activates human platelets via TRPM8-dependent and -independent mechanisms, with TRPM8 involved in early activation and ER calcium release driving later responses.

Antiviral activity of Pacific oyster (Crassostrea gigas) hemolymph against a human coronavirus.

This study evaluates the antiviral effect of Pacific oyster hemolymph against HCoV-229E, finding an eight-fold reduction in infectivity at 10% concentration.

Diverse Changes in Microglia Morphology and Axonal Pathology Over One Year after Mild Traumatic Brain Injury in Pigs

This study examines microglial morphology and axonal pathology in pigs with mild TBI over one year, finding persistent microglial morphological changes but no astrocyte reactivity or corpus callosum changes.

Evaluation of ExoU inhibitors in a Pseudomonas aeruginosa scratch infection assay

This study evaluates ExoU inhibitors in a Pseudomonas aeruginosa scratch infection model, showing their effectiveness in reducing cytotoxicity when combined with antimicrobials.

Single-cell profiling guided combinatorial immunotherapy for fast-evolving CDK4/6 inhibitor resistant HER2-positive breast cancer

This study uses single-cell profiling to identify immunosuppressive cells in CDK4/6 inhibitor-resistant HER2+ breast cancer and shows that combinatorial immunotherapy can overcome resistance.

KLK4 inhibition by cyclic and acyclic peptides: structural and dynamical insights into standard-mechanism protease inhibitors

This paper investigates how structural modifications in SFTI-based inhibitors affect their interaction with KLK4, revealing insights into protease inhibition dynamics.

Quality circles for quality improvement in primary health care: their effectiveness, gaps of knowledge, origins and significance - a scoping review

This scoping review evaluates quality circles in primary health care, finding they can effectively change behavior but require further research to understand their mechanisms and improve their use.