J. A. Lopez

Heterogeneity of the human immune response to malaria infection and vaccination driven by latent cytomegalovirus infection

This study shows that latent cytomegalovirus infection reduces antibody responses to malaria infection and vaccination by altering Tfh cell subsets and their activation.

Unfolded Von Willebrand Factor Binds Protein S and Reduces Anticoagulant Activity

This paper identifies a shear-dependent interaction between Protein S and von Willebrand Factor that reduces free PS anticoagulant activity and contributes to thrombotic risk in viral infections.

Lack of p38 activation in T cells increases IL-35 production and protects against obesity by promoting thermogenesis

This study shows that inhibiting p38 in T cells increases IL-35 production, which enhances thermogenesis and protects against obesity.

Cold temperature induces a TRPM8-independent calcium release from the endoplasmic reticulum in human platelets

This study shows cold temperature activates human platelets via TRPM8-dependent and -independent mechanisms, with TRPM8 involved in early activation and ER calcium release driving later responses.

Malaria drives unique regulatory responses across multiple immune cell subsets

The paper analyzes single-cell RNA sequencing data from malaria patients to identify immunoregulatory responses in specific immune cell subsets during infection and recovery.

Decoupling of mRNA and protein expression in aging brains reveals the age-dependent adaptation of specific gene subsets

The paper examines mRNA and protein expression changes in aging mouse brains, finding age-dependent gene subset adaptations with distinct transcriptional and translational responses.

STING activation promotes autologous type I interferon-dependent development of type 1 regulatory T cells during malaria

This study shows STING activation promotes Tr1 cell development during malaria by enhancing IFNB gene transcription and modulates this pathway with ruxolitinib.

Retrotransposons facilitate tissue-specific horizontal Transfer of circulating tumor DNA

This study shows retrotransposons enable tissue-specific horizontal gene transfer of circulating tumor DNA in cancer cells, influencing treatment response and opening new therapeutic avenues.

Cep55 regulation of PI3K/Akt signaling is required for neocortical development and ciliogenesis

This study shows that Cep55 regulates PI3K/Akt signaling, essential for neocortical development and ciliogenesis, using mouse models and human organoids.

The rise and fall of the ancient northern pike master sex determining gene

The paper traces the evolution of sex determination in northern pike, revealing an ancient origin of the master sex-determining gene and recent transitions including Y-chromosome loss.

ECM deposition is driven by caveolin1-dependent regulation of exosomal biogenesis and cargo sorting

This study shows caveolin-1 regulates exosome biogenesis and cargo sorting, driving ECM deposition and tumor cell invasiveness through cholesterol-dependent mechanisms.