Structural basis for PRC2 decoding of active histone methylation marks H3K36me2/3
K. Finogenova, J. Bonnet, S. Poepsel, I. B. Schäfer, K. Finkl, K. Schmid, C. Litz, M. Strauss, C. Benda, J. Müller
The paper determines how PRC2 is inhibited by H3K36 methylation through cryo-EM structures and shows that H3K36 mutations impair Polycomb repression.
bioRxiv · Apr 22, 2020Biochemistry