Epigenetic reprogramming towards mesenchymal-epithelial transition in ovarian cancer-associated mesenchymal stem cells drives metastasis
H. Fan, H. Atiya, Y. Wang, T. Pisanic, J. Wang, I.-M. Shih, K. Foy, L. Frisbie, C. Chandler, H. Shen, L. G. Coffman
This paper shows epigenetic reprogramming of mesenchymal stem cells into CA-MSCs drives ovarian cancer metastasis through partial MET and WT1/EZH2-mediated mechanisms.
bioRxiv · Feb 25, 2020Cancer Biology