Pooled screening of CAR T cells identifies non-native signaling domains for next- generation immunotherapies
D. B. Goodman, C. S. Azimi, K. Kearns, K. Garakani, J. Garcia, N. Patel, B. Hwang, D. Lee, E. Park, C. J. Ye, A. Marson, J. Bluestone, K. Roybal
This study identifies non-native signaling domains in CAR T cells that enhance proliferation or cytotoxicity, offering improved designs for immunotherapies.
bioRxiv · Jul 11, 2021 · PreprintImmunology