A. Marson

NKp30 and NKG2D contribute to natural killer recognition of HIV-infected cells

This study identifies NKp30:B7-H6 and NKG2D:MICB/ULBP2 as receptor-ligand pairs that contribute to NK cell recognition of HIV-infected cells.

Multiplexed CRISPR gene editing in primary human islet cells with Cas9 ribonucleoprotein

This study uses CRISPR/Cas9 RNP to edit regulatory DNA elements in human islet cells, revealing their role in diabetes risk and β cell function.

Polygenic risk score analysis reveals shared genetic burden between epilepsy and psychiatric comorbidities

This study uses polygenic risk scores to show that people with epilepsy have increased genetic risk for depression, psychosis, and ADHD, with stronger associations in drug-resistant cases.

Non-coding sequence variation reveals fragility within interleukin 2 feedback circuitry and shapes autoimmune disease risk

The paper shows how non-coding variants affecting IL2RA enhancers alter T cell feedback circuits, leading to opposing autoimmune outcomes in mice.

The lncRNA Malat1 Inhibits miR-15/16 to Enhance Cytotoxic T Cell Activation and Memory Cell Formation

This study identifies Malat1 as a regulator of miR-15/16 in cytotoxic T cells, showing that disrupting their interaction impairs T cell activation and memory formation.

Dynamic phosphatase-recruitment controls B-cell selection and oncogenic signaling

This study identifies CD25 as a scaffold for phosphatases that regulate B-cell signaling and oncogenic processes, with opposing effects on B-cell malignancies and autoimmunity.

Modular Pooled Discovery of Synthetic Knockin Sequences to Program Durable Cell Therapies

The paper develops ModPoKI, a platform for modular construction of DNA knockin libraries to identify gene constructs that enhance T cell function and persistence.

Genome-wide CRISPR screens of T cell exhaustion identify chromatin remodeling factors that limit T cell persistence

This study identifies chromatin remodeling factors that limit T cell persistence using CRISPR screens and shows their impact on anti-tumor immunity.

Microbial signals and lymphotoxin drive TNF-independent death of A20 and ABIN-1 deficient epithelium

The paper shows that microbial signals, MyD88, and lymphotoxin contribute to TNF-independent intestinal injury after A20 and Abin-1 deletion in intestinal epithelial cells.

CRISPR-Cas9 mediated nuclear transport and genomic integration of nanostructured genes in human primary cells

This study delivers DNA nanostructures into human primary cells using CRISPR-Cas9, achieving efficient genomic integration with lower toxicity than dsDNA.

Pooled screening of CAR T cells identifies non-native signaling domains for next- generation immunotherapies

This study identifies non-native signaling domains in CAR T cells that enhance proliferation or cytotoxicity, offering improved designs for immunotherapies.

Hypoxia is a dominant remodeler of the CD8+ T cell surface proteome relative to activation and regulatory T cell-mediated suppression

This study compares how hypoxia and regulatory T cells affect the CD8+ T cell surface proteome, finding hypoxia has a more significant impact than Treg-mediated suppression.

CRISPR activation and interference screens in primary human T cells decode cytokine regulation

The paper uses CRISPR activation and interference screens in primary human T cells to identify cytokine regulators, finding genes like FOXQ1 that influence cytokine production and immune cell functions.

T cell subset-selective IL2RA enhancers shape autoimmune diabetes risk

This study identifies two enhancers regulating IL2RA expression in T cells, showing how their cell-type-specific effects influence autoimmune diabetes risk.

A negative feedback loop mediated by the NR4A family of nuclear hormone receptors restrains expansion of B cells that receive signal one in the absence of signal two

This study identifies a negative feedback loop involving NR4A receptors that limits B cell proliferation without T cell help and enhances antibody responses to T-independent antigens.

CRISPR Screen in Regulatory T Cells Reveals Ubiquitination Modulators of Foxp3

This study uses a CRISPR screen in mouse Tregs to identify genes regulating Foxp3 expression, finding Usp22 and Atxn7l3 as stabilizers and Rnf20 as a destabilizer.

TCF-1 regulates the stem-like memory potential of HIV-specific CD8+ T cells in elite controllers

The paper shows TCF-1 enhances HIV-specific CD8+ T cell expansion and memory properties in elite controllers.

Global post-translational modification profiling of HIV-1-infected cells reveals mechanisms of host cellular pathway remodeling

The paper uses proteomics to analyze PTM changes in HIV-1-infected cells, identifying mechanisms of host pathway remodeling through Aurora kinase A and PP2A modulation.

Rewired signaling network in T cells expressing the chimeric antigen receptor (CAR)

This study shows CAR T cells bypass LAT for some signaling outputs but still require it for IL-2 production, revealing a rewired signaling pathway.

Dysregulated RASGRP1 expression through RUNX1 mediated transcription promotes autoimmunity

The paper shows that reduced RASGRP1 expression, regulated by RUNX1, contributes to autoimmunity by impairing T cell function and increasing inflammation.

Obesity Potentiates TH2 Immunopathology via Dysregulation of PPAR

This study shows obesity increases TH2 immunopathology by disrupting PPARγ in T cells, and TZDs can protect against this effect in obese mice.

Rapid discovery of synthetic DNA sequences to rewrite endogenous T cell circuits

This paper develops a platform to discover synthetic DNA sequences that enhance T cell functions by integrating them into endogenous genomic sites.

A Cas9 nanoparticle system with truncated Cas9 target sequences on DNA repair templates enhances genome targeting in diverse human immune cell types

The paper improves non-viral CRISPR-Cas9 genome editing in immune cells by using truncated Cas9 target sequences and polymer-stabilized nanoparticles, enhancing efficiency and viability.

Systematic characterization of genome editing in primary T cells reveals proximal genomic insertions and enables machine learning prediction of CRISPR-Cas9 DNA repair outcomes

This study systematically characterizes genome editing in primary T cells, identifies proximal genomic insertions, and develops a machine learning model to predict CRISPR-Cas9 DNA repair outcomes.

Genome-wide CRISPR Screens in Primary Human T Cells Reveal Key Regulators of Immune Function

This study uses CRISPR screens in primary human T cells to identify regulators of immune function and cancer cell killing.

Light-Activated Cell Identification and Sorting (LACIS): A New Method to Identify and Select Edited Clones on a Microfluidic Device

The paper introduces LACIS, a microfluidic method for identifying and sorting edited clones using Opto-Electronic Positioning, enabling rapid and efficient clonal selection after CRISPR-Cas9 editing.