E. Park

Substrate recognition mechanism of the endoplasmic reticulum-associated ubiquitin ligase Doa10

This study defines the substrate recognition mechanism of Doa10 using structural and functional analyses in yeast, revealing a lateral tunnel and fence-like domains that facilitate substrate access.

An RXLR effector targets ER-Golgi interface to induce ER stress and necrotic cell death

This study identifies Pc12, an RXLR effector from P. capsici, which induces necrotic cell death by disrupting ER-Golgi trafficking through interaction with Rab13-2.

A deep lung cell atlas reveals cytokine-mediated lineage switching of a rare cell progenitor of the human airway epithelium

This study identifies a rare progenitor cell population in the human airway that can differentiate into ionocytes or tuft cells, and shows cytokines can shift their lineage towards tuft cells in asthma and CF.

Enhanced fungal specificity and in vivo therapeutic efficacy of a C-22 modified FK520 analog against C. neoformans

This paper identifies a modified FK520 analog, JH-FK-08, with reduced immunosuppression and improved antifungal efficacy against C. neoformans in vivo.

Shear-induced phenotypic transformation of microglia in vitro

This study investigates how fluid shear stress affects microglia morphology and activation, finding that shear flow promotes a shift toward pro-inflammatory states.

ACCELERATING ANTIBODY DESIGN WITH ACTIVE LEARNING

The paper develops a sequence generation model using transfer and active learning to efficiently discover binding antibodies with novel HCDR3 regions, requiring only six thousand data points per antigen.

A common mechanism of Sec61 translocon inhibition by small molecules

This study identifies a common binding site for diverse Sec61 inhibitors and shows how they stabilize the plug domain to block protein translocation.

Cryo-EM structure of a RAS/RAF recruitment complex

The paper presents cryo-EM structures of a KRAS/BRAF/MEK1/14-3-3 complex, showing KRAS binding to BRAF's Ras-binding domain without activating it, suggesting stabilization of a pre-activation intermediate as a therapeutic target.

PH Domain-Mediated Autoinhibition and Oncogenic Activation of Akt

This study identifies a mutation in the PH domain of Akt that enhances autoinhibition and reveals the molecular mechanism of Akt activation as an oncogenic driver.

Mitigating the Bfl-1-mediated antiapoptotic pathway in diffuse large B cell lymphoma by inhibiting HDACs

The paper withdraws due to the need for further experiments to validate conclusions about Bfl-1 and HDAC inhibition in diffuse large B cell lymphoma.

Structure-guided synthesis of FK506 and FK520 analogs with increased selectivity exhibit in vivo therapeutic efficacy against Cryptococcus

This paper develops FK506 analogs with improved fungal selectivity and antifungal efficacy, showing reduced immunosuppression and therapeutic benefit in fungal infection models.

Structural basis of mitochondrial protein import by the TIM complex

The paper determines the cryo-EM structure of the yeast TIM complex, revealing that Tim17 forms the protein translocation path while Tim23 provides structural support.

Cryo-ET of a human GBP coatomer governing cell-autonomous innate immunity to infection

The paper solves the native structure of a human GBP coatomer that coats cytosolic bacteria and functions as an antimicrobial signaling platform.

A hierarchical GBP network promotes cytosolic LPS recognition and sepsis

The paper identifies a hierarchical GBP network that regulates cytosolic LPS recognition and sepsis by coordinating caspase-11 and gasdermin D functions.

Pooled screening of CAR T cells identifies non-native signaling domains for next- generation immunotherapies

This study identifies non-native signaling domains in CAR T cells that enhance proliferation or cytotoxicity, offering improved designs for immunotherapies.

Structural basis of polyamine transport by human ATP13A2 (PARK9)

This study determines cryo-EM structures of ATP13A2 to elucidate its polyamine transport mechanism and structural basis for specificity.

NK cell metabolic adaptation to infection promotes survival and viral clearance.

This study shows HIF-1 is essential for NK cell survival and viral clearance during MCMV infection by regulating metabolism and preventing apoptosis.

Stepwise gating of the Sec61 protein-conducting channel by Sec63 and Sec62

This study reveals the stepwise gating mechanism of the Sec61 channel by Sec62 and Sec63 using cryo-EM structures of the translocation complex.

Enriching neural stem cell and pro-healing glial phenotypes with electrical stimulation after traumatic brain injury in male rats

This study shows that electrical stimulation after traumatic brain injury in rats promotes pro-healing microglia phenotypes, increases neural stem cells and Nestin+ astrocytes, and enhances neuronal viability.

Torix group Rickettsia are widespread in New Zealand freshwater amphipods: using blocking primers to rescue host COI sequences

The paper detects Torix group Rickettsia in New Zealand freshwater amphipods and develops blocking primers to obtain host COI sequences for DNA barcoding.

Protective effect of agmatine against cisplatin-induced apoptosis in an auditory cell line

This study evaluates agmatine's protective effect against cisplatin-induced apoptosis in HEI-OC1 auditory cells, showing reduced BAX and caspase-3 activity.

Cryo-EM structure of the mitochondrial protein-import channel TOM complex from Saccharomyces cerevisiae.

The paper presents cryo-EM structures of the TOM complex from Saccharomyces cerevisiae, revealing its molecular organization and mechanism of protein translocation.

Toxoplasma gondii infection drives conversion of NK Cells into ILC1s

This study shows Toxoplasma gondii infection converts NK cells into ILC1-like cells that persist and circulate independently of infection.

Bioresponsive Microspheres for On-demand Delivery of Anti-inflammatory Cytokines for Osteoarthritis

This paper develops bioresponsive microspheres that release anti-inflammatory cytokines on-demand in osteoarthritic joints, reducing inflammation and preserving cartilage.

A human pathogenic bacterium Shigella proliferates in the plant through the adoption of type III effectors for Shigellosis

This study shows Shigella strains proliferate in Arabidopsis plants using type III effectors similar to their role in human infections.

Genetic Diversity Patterns and Domestication Origin of Soybean

The paper analyzes genetic diversity in soybean to determine domestication origin and identify loci associated with domestication traits.

Impact of Chronic Total Occlusion Lesion Length onSix-month Angiographic and 2-year Clinical Outcomes

This study compares 6-month angiographic and 2-year clinical outcomes between long and short chronic total occlusion (CTO) lesions after successful DES PCI, finding higher repeat PCI rates in long CTO lesions.