Itaconate and its derivatives repress C2C12 myogenesis
T. Oh, D. Hutchins, R. Mainali, K. Goslen, M. A. Quinn
This study shows itaconate and its derivatives inhibit C2C12 myogenesis by blocking succinate dehydrogenase, suggesting potential limitations in their therapeutic use for inflammatory diseases.
bioRxiv · Feb 1, 2021 · PreprintCell Biology