Author

R. Mainali

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 1 Immunology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Organism:mouse· 3 Approach:experimental assay· 2 Research Focus:metabolism & bioenergetics· 2 Assay:proteomics· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1

Frequent Co-Authors

M. A. Quinn· 3 shared C. Furdui· 2 shared C.-C. Key· 2 shared N. Buechler· 2 shared C. E. McCall· 1 shared C. Ortero· 1 shared D. Hutchins· 1 shared D. Long· 1 shared

Activity by Year

2021-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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3 shared papersPhysiology

M. A. Quinn

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Itaconate stabilizes CPT1a to enhance lipid utilization during inflammation

R. Mainali, N. Buechler, C. Ortero, L. Edwards, C.-C. Key, C. Furdui, M. A. Quinn

This study shows itaconate stabilizes CPT1a to enhance lipid utilization during inflammation, revealing a novel metabolic role in modulating fatty acid oxidation during sepsis.

bioRxiv · Aug 14, 2023Physiology

Dichloroacetate reverses sepsis-induced hepatic metabolic dysfunction

R. Mainali, M. Zabalwi, D. Long, N. Buechler, E. Quillen, C.-C. Key, X. Zhu, J. Parks, C. Furdui, P. Stacpoole, J. Martinez, C. E. McCall, M. A. Quinn

This study shows dichloroacetate reverses sepsis-induced hepatic metabolic dysfunction by targeting mitochondrial PDC/PDK energy homeostasis in a mouse model.

eLife · Feb 22, 2021Peer-reviewedImmunology

Itaconate and its derivatives repress C2C12 myogenesis

T. Oh, D. Hutchins, R. Mainali, K. Goslen, M. A. Quinn

This study shows itaconate and its derivatives inhibit C2C12 myogenesis by blocking succinate dehydrogenase, suggesting potential limitations in their therapeutic use for inflammatory diseases.

bioRxiv · Feb 1, 2021 · PreprintCell Biology