M. A. Quinn

This study shows itaconate stabilizes CPT1a to enhance lipid utilization during inflammation, revealing a novel metabolic role in modulating fatty acid oxidation during sepsis.

This study shows that inhibiting PDHK reduces NLRP3 inflammasome activation in macrophages, decreasing inflammation and tissue damage.

This study shows that dichloroacetate improves energy balance and feeding behavior in sepsis by reversing metabolic dysfunctions and glycine deficiency.

This study shows dichloroacetate reverses sepsis-induced hepatic metabolic dysfunction by targeting mitochondrial PDC/PDK energy homeostasis in a mouse model.

This study shows itaconate and its derivatives inhibit C2C12 myogenesis by blocking succinate dehydrogenase, suggesting potential limitations in their therapeutic use for inflammatory diseases.

This study examines the effects of advanced maternal age on pregnancy adaptations in vervet monkeys, finding physiological changes similar to human AMA pregnancies.