Brain-Restricted mTOR Inhibition with Binary Pharmacology
Z. Zhang, Q. Fan, X. Luo, K. J. Lou, W. A. Weiss, K. Shokat
This paper describes a strategy to achieve brain-restricted mTOR inhibition using a combination of a brain-permeable inhibitor and a brain-impermeable ligand, while preserving systemic mTOR activity.
bioRxiv · Oct 12, 2020Cancer Biology