X. Luo

The cGAS-STING Pathway Is Essential in Acute Ischemia-Induced Neutropoiesis and Neutrophil Priming in the Bone Marrow

This study shows that the cGAS-STING pathway is essential for neutrophil production and function in the bone marrow during acute myocardial ischemia, promoting myocardial repair.

Phase transition of WTAP regulates m6A modification of interferon-stimulated genes

The paper shows WTAP undergoes phase transition during IFN-β stimulation to regulate m6A modification of ISG mRNAs and control their expression.

YTHDF2 upregulation and relocation dictate CD8 T cell polyfunctionality in tumor immunity

This paper shows YTHDF2 upregulation and nuclear relocation enhance CD8 T cell polyfunctionality and tumor immunity by regulating gene transcription and mitochondrial fitness.

Development of an engineered extracellular vesicles-based vaccine platform for combined delivery of mRNA and protein to induce functional immunity

This paper develops an engineered extracellular vesicles-based vaccine platform for combined mRNA and protein delivery, showing tumor regression and immune responses in preclinical models.

Comparative transcriptome analysis provides insights into the resistance regulation mechanism and inhibitory effect of fungicide phenamacril in Fusarium asiaticum

This study identifies DEGs and their roles in phenamacril resistance in Fusarium asiaticum through comparative transcriptome analysis of sensitive and resistant strains.

Three-dimensional Isotropic Imaging of Live Suspension Cells Enabled by Droplet Microvortices

This paper introduces ADOPT, a method for 3D isotropic imaging of live suspension cells using microfluidic droplets and OPT, revealing distinct nuclear content distributions in immune cells.

Phase-changing citrate macromolecule combats oxidative pancreatic islet damage, enables islet engraftment and function in the omentum

PPCN, a thermoresponsive antioxidant polymer, supports islet viability and function in nonhuman primates when used for omentum transplantation.

Single Cell Expression Analysis of Ductal Carcinoma in Situ Identifies Alterations in Epithelial Integrity

This study uses scRNA-seq to analyze DCIS and normal breast tissue, identifying clonal heterogeneity and cell state changes associated with progression to invasive cancer.

G6PD Maintains Redox Homeostasis and Biosynthesis in LKB1-Deficient KRAS-Driven Lung Cancer

This study shows that G6PD is critical for redox balance and biosynthesis in LKB1-deficient KRAS-driven lung cancer, but not in KP tumors, and identifies potential therapeutic strategies.

Comparative single-cell regulome reveals evolutionary innovations in neural progenitor cells during primate corticogenesis

The paper compares single-cell regulomes of macaque and mouse neural progenitors with human data to identify evolutionary changes in cortex development.

Habitat correlates of cave-dwelling: A radiation-scale analysis of skin traits and comparative transcriptomics of the Sinocyclocheilus cavefish

This study identifies habitat-related transcriptional differences in skin traits of Sinocyclocheilus cavefish using comparative transcriptomics and RNA-seq.

An Interleukin 9-Zbtb18 axis promotes germinal center development of memory B cells

This study identifies an Il-9-Zbtb18 axis that promotes the development of memory B cells from germinal centers by regulating cell cycle, survival, and GC exit.

Post-acute immunological and behavioral sequelae in mice after Omicron infection

This study investigates post-acute immunological and behavioral effects in mice after Omicron infection, showing vaccination reduces pulmonary immune perturbations and behavioral deficits.

A gene silencing pipeline to interrogate human cDC1 and pDC development and functions

This paper develops a gene silencing pipeline to study human cDC1 and pDC development and functions, identifying key regulators and HIV-1 restriction factors.

Insight into the genetic diversity, resistance, and virulence of Listeria from the marine environment: reveal the risk of hypervirulent isolates

This study examines Listeria species in beach sand, identifying hypervirulent isolates and their potential role in human listeriosis.

Resolving the developmental mechanisms of coagulation abnormalities characteristic of SARS-CoV2 based on single-cell transcriptome analysis

This study uses single-cell transcriptome analysis to identify immune and metabolic mechanisms underlying coagulation abnormalities in SARS-CoV-2 infection.

Gene expression plasticity followed by genetic change during colonization a high-elevation environment

The paper quantifies gene expression plasticity and genetic change in Eurasian Tree Sparrows during high-elevation colonization, showing plasticity is often reversed or reinforced through selection.

Long COVID manifests with T cell dysregulation, inflammation, and an uncoordinated adaptive immune response to SARS-CoV-2

This study identifies T cell dysregulation, inflammation, and mis-coordinated adaptive immune responses in Long COVID patients compared to non-LC individuals.

Pretrained language models and weight redistributionachieve precise kcat prediction

This paper introduces PreKcat, a model that accurately predicts kcat values using pretrained language models and weight redistribution, outperforming existing methods.

A novel method revealing animal evolutionary relationships based on milk Mid-infrared

This study uses mid-infrared spectra of milk to establish models for assessing mammalian evolutionary relationships and genetic distances with high accuracy.

Epigenetic silencing by SMYD3 represses tumor intrinsic interferon response in HPV-negative squamous cell carcinoma of the head and neck.

This study identifies SMYD3 as an epigenetic regulator that suppresses the intrinsic interferon response in HPV-negative HNSCC, offering a potential strategy to enhance immunotherapy response.

Targeting the Immune-Fibrosis Axis in Myocardial Infarction and Heart Failure

The paper identifies a fibroblast trajectory associated with cardiac fibrosis and shows that macrophage-fibroblast crosstalk via IL-1β signaling drives fibrosis.

Subcutaneous BCG vaccination protects against streptococcal pneumonia via regulating innate immune responses in the lung

This study shows subcutaneous BCG vaccination enhances innate protection against Streptococcus pneumoniae by accelerating neutrophilia in the lung, independent of monocyte training.

Sensitive bacterial Vm sensors revealed the excitability of bacterial Vm and its role in antibiotic tolerance

The paper develops bacterial Vm sensors to study Vm dynamics and shows that excitable states enhance antibiotic tolerance.

Discovery of a new class of reversible TEA-domain transcription factor inhibitors with a novel binding mode

This paper identifies a new class of TEAD-YAP inhibitors with a novel binding mode that suppresses transcriptional activity and shows anti-proliferative effects in cancer cells.

Ralstonia solanacearum effector RipAF1 ADP-ribosylates host FBN1 to induce resistance against bacterial wilt

This study identifies RipAF1 as an effector that ADP-ribosylates host FBN1, inducing resistance against bacterial wilt by disrupting disease signaling.

Mutations in the spike RBD of SARS-CoV-2 omicron variant may increase infectivity without dramatically altering the efficacy of current multi-dosage vaccinations

The paper analyzes mutations in the SARS-CoV-2 omicron spike RBD, finding increased hydrophilic regions that may enhance infectivity but suggest that multi-dose vaccines can still provide protection against severe disease.

IGF1 Signaling in Temporomandibular Joint Fibrocartilage Stem Cells Regulates Cartilage Growth and Homeostasis in Mice

This study shows that Igf1 deletion in TMJ fibrocartilage stem cells causes cartilage degeneration and worsens osteoarthritis in mice.

Deep Phenotypic Analysis of Blood and Lymphoid T and NK Cells from HIV+ Controllers and Non-Controllers

This study compares T and NK cell phenotypes in blood and lymph nodes of HIV+ controllers and ART-treated individuals, finding distinct cellular features in lymphoid tissues.

Vernalization-triggered expression of the antisense transcript COOLAIR is mediated by CBF genes

This study shows that CBF genes regulate COOLAIR expression during vernalization in Arabidopsis, but COOLAIR is not essential for the vernalization response.