Q. Fan

Nightmare or delight: taxonomic circumscription meets reticulate evolution in the phylogenomic era

The paper investigates reticulate evolution in the genus Stranvaesia using phylogenomic data, revealing how hybridization and allopolyploidy influence taxonomic classification and leading to the description of a new genus.

Multiple sites on glycoprotein H (gH) functionally interact with the gB fusion protein to promote fusion during herpes simplex virus (HSV) entry

This study identifies two gH mutations (H789Y and S830N) that partially restore HSV-1 entry function when paired with specific gB variants, suggesting functional interaction sites between gH/gL and gB.

Biphasic curvature-dependence of cell migration inside microcylinders: persistent randomness versus directionality

The paper studies how cell migration inside microcylinders depends on curvature, finding a biphasic relationship with changes in speed, anisotropy, and persistence.

Somatic nuclear blebbing may indicate proliferating germ cells but does not indicate organismal aging in Caenorhabditis elegans

This study examines nuclear blebbing in C. elegans, finding it accumulates with age and contributes to chromatin loss, but is not linked to aging rate or stress, and is promoted by germ cell proliferation.

Optimized path planning surpasses human efficiency in cryo-EM imaging

This paper introduces an algorithm called cryoRL that uses reinforcement learning to optimize cryo-EM data collection, outperforming human operators in efficiency and image quality.

Delivery of Circular mRNA via Degradable Lipid Nanoparticles against SARS-COV-2 Delta Variant

This study develops a stable and safe mRNA vaccine (cmRNA-1130) using degradable lipid nanoparticles against the SARS-CoV-2 Delta variant, showing potent immune responses and stability.

Extensive neutralization against SARS-CoV-2 variants elicited by Omicron-specific subunit vaccine booster

This study shows that an Omicron-specific subunit vaccine booster enhances neutralizing antibodies against SARS-CoV-2 variants and the ancestral virus, with a two-dose WT-RBD plus Omicron-RBD booster showing the strongest response.

Molecular basis of broad neutralization against SARS-CoV-2 variants including Omicron by a human antibody

A human antibody, VacW-209, broadly neutralizes SARS-CoV-2 variants including Omicron by targeting a conserved epitope, highlighting the importance of such antibodies in pandemic control.

Potent antibody immunity to SARS-CoV-2 variants elicited by a third dose of inactivated vaccine

A third dose of inactivated SARS-CoV-2 vaccine significantly enhances plasma neutralization and generates high-affinity anti-RBD memory B cells against variants like Beta, Delta, and Lambda.

Hyaluronidase-1-mediated glycocalyx impairment underlies endothelial abnormalities in polypoidal choroidal vasculopathy

This study identifies hyaluronidase-1 as a key driver of glycocalyx impairment in PCV BOECs, linking it to endothelial dysfunction and proposing it as a therapeutic target.

Brain-Restricted mTOR Inhibition with Binary Pharmacology

This paper describes a strategy to achieve brain-restricted mTOR inhibition using a combination of a brain-permeable inhibitor and a brain-impermeable ligand, while preserving systemic mTOR activity.

Improved cortical surface reconstruction using sub-millimeter resolution MPRAGE by image denoising

This paper evaluates denoising methods for sub-millimeter T1-weighted MR images to improve cortical surface reconstruction accuracy without requiring multiple repetitions.

Loss of Bone Morphogenetic Protein-binding Endothelial Regulator Causes Insulin Resistance

This study shows BMPER deficiency leads to insulin resistance and hyperglycemia, and BMPER therapy improves these conditions in mice.

Garcinia cambogia extract removes calcium oxalate kidney stones in both genetic and non-genetic Drosophila models of nephrolithiasis

This study shows Garcinia cambogia extract removes calcium oxalate kidney stones in Drosophila models, suggesting a potential therapeutic strategy for nephrolithiasis.

Natural selection of glycoprotein B (gB) mutations that rescue the small plaque phenotype of a fusion-impaired herpes simplex virus (HSV) mutant

This study identifies mutations in herpes simplex virus gB that restore fusion function and plaque size in a fusion-impaired mutant.

OGT (O-GlcNAc Transferase) selectively modifies multiple residues unique to lamin A

This study identifies O-GlcNAc modifications unique to lamin A, showing OGT modifies specific residues in lamin A tails but not lamin B1, lamin C, or progerin.