Engineering multivalent Fc display for FcγR blockade
E. Petrova, G. Kiriako, J. Rebetz, K. Johansson, S. Wennmalm, N. E. J. Meijer, B. M. Hällberg, I. Andre, E. Ambrosetti, J. W. Semple, A. I. Teixeira
This study engineers multivalent Fc-displaying virus-like particles to block FcγR activation, showing that higher valency reduces receptor activation and enhances inhibition of immune complex-mediated phagocytosis.
bioRxiv · Jan 20, 2024 · PreprintBioengineering