D. Cheng

PGC-1a drives small cell neuroendocrine cancer progression towards an ASCL1-expressing subtype with increased mitochondrial capacity

HOIL1 mediates MDA5 activation through ubiquitination of LGP2

This study shows HOIL1 ubiquitinates LGP2 to activate MDA5 and induce IFN responses, highlighting a mechanism distinct from RIG-I sensing.

Labeling Natural Killer cells with superparamagnetic iron oxide nanoparticles for detection by preclinical and clinical-scale magnetic particle imaging

This study labels NK cells with iron oxide nanoparticles and demonstrates their detection using magnetic particle imaging in preclinical and clinical settings.

AAV eluting lenses for single-step targeted expression of genetically- encoded activity sensors for in vivo microendoscopic calcium imaging

This paper develops AAV-eluting lenses for single-step targeted expression of GCaMP in vivo, improving alignment and surgical flexibility for microendoscopic calcium imaging.

A novel bacterial signal transduction system specifically senses and responds to peptidoglycan damage

This study identifies a bacterial two-component system that detects and responds to peptidoglycan damage, revealing its role in antibiotic resistance and tolerance.

A toxic ankyrin cysteine protease effector RipBH of brown rot triggered autophagy-associated cell death

The paper identifies RipBH, a virulent type III effector from Ralstonia solanacearum, which induces autophagy-associated cell death and is essential for potato brown rot pathogenesis.

Broadly effective ACE2 decoy proteins protect mice from lethal SARS-CoV-2 infection

This paper develops two ACE2 decoy proteins that neutralize diverse SARS-CoV-2 variants and protect mice from lethal infection with high survival rates.

Defining T cell receptor repertoires using nanovial-based affinity and functional screening

This study uses nanovials to screen antigen-specific T cells based on affinity and function, identifying a more specific functional TCR repertoire than standard techniques.

Human CCR6+ Th cells show both an extended stable gradient of Th17 activity and imprinted plasticity

The paper identifies an extended gradient of Th17 activity in human CCR6+ Th cells, showing both stable phenotypes and plasticity under different activation conditions.

Proliferative Exhausted CD8 T Cells Exacerbate Long-lasting Anti-tumor Effects in Human Papillomavirus Positive Head and Neck Squamous Cell Carcinoma

The paper identifies a proliferative exhausted CD8+ T cell cluster in HPV-positive HNSCC that correlates with better patient survival and suggests potential therapeutic implications.

Cell-free Tumor Methylome Analysis of Small Cell Lung Cancer Patients Identifies Subgroups with Prognostic Associations

This study uses cfMeDIP-seq to analyze cell-free methylomes in SCLC patients, identifying prognostic methylome clusters associated with biological pathways and repeat elements.

A genotype independent DMP-HI system in dicot crops

This paper demonstrates a genotype-independent in vivo haploid induction system in dicot crops by mutating DMP genes, achieving HI rates of 1.9%, 2.4%, and 1.2% in tomato, rapeseed, and tobacco respectively.

Factors Shaping Young and Mature Bacterial Biofilm Communities in Two Drinking Water Distribution Networks

The paper studies bacterial biofilm communities in two drinking water distribution systems, finding that mature biofilms are influenced by water chemistry and pipe characteristics, while young biofilms are linked to orthophosphate and stagnation indicators.

Rectal bacteria produce sex pheromones in the male oriental fruit fly

This study shows that bacteria in the rectum of male oriental fruit flies produce sex pheromones, specifically TMP and TTMP, which attract females.

Modified N-linked glycosylation status predicts trafficking defective human Piezo1 channel mutations

The paper shows that N-linked glycosylation in Piezo1 channels is essential for plasma membrane trafficking and that mutations affecting this process are linked to disease.

Identification of compounds producing non-visual photosensation via TrpA1 in zebrafish

The paper identifies compounds that induce non-visual photosensation via TRPA1 in zebrafish by increasing light-elicited motor activity.

Egg-surface bacteria deter oviposition by the oriental fruit fly Bactrocera dorsalis

The paper shows that egg-surface bacteria in Bactrocera dorsalis increase β-caryophyllene in fruits, deterring oviposition by conspecific flies.

Flow cytometric analysis and purification of airway epithelial cell subsets

The paper develops flow cytometric panels to isolate human airway epithelial subsets using scRNA-seq data and cell type markers, identifying subpopulations and low-abundance transcripts in secretory cells.

Force-dependent recruitment of Piezo1 drives focal adhesion maturation and calcium entry in normal but not tumor cells

The paper shows Piezo1 binds to matrix adhesions in a force-dependent manner in normal cells, promoting adhesion maturation and calcium entry, but not in tumor cells.

A Micro-Engineered Airway Lung-Chip Models Key Features of Viral-Induced Exacerbation of Asthma

This paper develops a micro-engineered Airway Lung-Chip model that replicates viral-induced asthma exacerbation features and evaluates immunomodulatory therapies.

Calcium imaging in freely-moving mice during electrical stimulation of deep brain structures

This paper describes a method combining chronic calcium imaging and deep brain stimulation in a Parkinson's disease mouse model to study neuromodulation effects.

The Novel Monocomponent FAD-dependent Monooxygenase HpaM Catalyzes the 2-Decarboxylative Hydroxylation of 5-Hydroxypicolinic Acid in Alcaligenes faecalis JQ135

This paper identifies HpaM, a novel FAD-dependent monooxygenase in Alcaligenes faecalis JQ135, which catalyzes 2-decarboxylative hydroxylation of 5HPA to produce 2,5-DPH.