Author

K. K. Sharp

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Biophysics· 1

Signature Assays, Organisms & Methods

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Assay:DNA methylation· 1 Assay:long-read sequencing· 1 Research Focus:sequence-to-function modeling· 1 Approach:statistical model· 1

Frequent Co-Authors

D. Mathews· 1 shared H. Sun· 1 shared J. D. Kahn· 1 shared M. Zhu· 1 shared R. J. Peterson· 1 shared S. A. Benner· 1 shared S. Hoshika· 1 shared T. M. Pham· 1 shared

Activity by Year

2023-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperBiophysics

D. Mathews

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1 paper

Recent·Most cited

DNA Structure Design Is Improved Using an Artificially Expanded Alphabet of Base Pairs Including Loop and Mismatch Thermodynamic Parameters

T. M. Pham, T. Miffin, H. Sun, K. K. Sharp, X. Wang, M. Zhu, S. Hoshika, R. J. Peterson, S. A. Benner, J. D. Kahn, D. Mathews

This paper improves DNA structure design by introducing a new base pair alphabet with P-Z pairs and thermodynamic parameters, enhancing design accuracy and reducing off-target folding.

bioRxiv · Jun 6, 2023Biophysics