K. L. Dulwich

Transcriptomic analysis reveals that severity of infectious bursal disease in White Leghorn inbred chicken lines is associated with greater bursal inflammation in vivo and more rapid induction of pro-inflammatory responses in primary bursal cells stimulated ex vivo.

This study compares the transcriptomic responses of inbred chicken lines to IBDV infection, finding that severe disease correlates with enhanced inflammation and faster pro-inflammatory gene induction in bursal cells.

The stronger downregulation of in vitro and in vivo innate antiviral responses by a very virulent strain of infectious bursal disease virus (IBDV), compared to a classical strain, is mediated, in part, by the VP4 protein.

This study compares the innate antiviral responses of two IBDV strains, showing that the very virulent UK661 strain suppresses IFN and proinflammatory gene expression more than the classical F52/70 strain, mediated in part by the VP4 protein.

Differential gene expression in chicken primary B cells infected ex vivo with attenuated and very virulent strains of infectious bursal disease virus (IBDV)

This study compares gene expression in chicken B cells infected with attenuated and very virulent IBDV strains to identify differences in immune response and virulence factors.