Author

A. J. Broadbent

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 6 Ecology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Organism:chicken / avian· 4 Research Focus:host-pathogen & immune response· 4 Assay:bulk RNA-seq· 3 Research Focus:cell type annotation· 3 Research Focus:differential expression· 2 Assay:electronic health records· 1 Assay:fluorescence / live-cell microscopy· 1

Frequent Co-Authors

S. Nazki· 4 shared E. S. Giotis· 3 shared K. L. Dulwich· 3 shared M. A. Skinner· 3 shared A. G. Gray· 2 shared E. A. Campbell· 2 shared J. Simpson· 2 shared J. Wells· 2 shared

Activity by Year

2017-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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4 shared papersMicrobiology

S. Nazki

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

Genetic diversity, recombination and cross-species transmission of a waterbird gammacoronavirus in the wild

S. Francois, S. Nazki, S. H. Vickers, G. Fournie, C. M. Perrins, A. J. Broadbent, O. G. Pybus, S. C. Hill

The paper characterizes a gammacoronavirus in waterbirds, revealing its genetic diversity, recombination origin, and cross-species transmission potential.

bioRxiv · Jun 8, 2023Ecology

Evaluating the breadth of neutralizing antibody responses elicited by infectious bursal disease virus (IBDV) genogroup A1 strains using a novel chicken B-cell rescue system and neutralization assay

V. R. Reddy, S. Nazki, A. J. Brodrick, A. Asfor, J. Urbaniec, Y. Morris, A. J. Broadbent

This study evaluates neutralizing antibody responses against different IBDV genogroups using a novel chicken B-cell rescue system and neutralization assays, showing A1 strains are most antigenically distant from A2 and other genogroups.

bioRxiv · Jun 3, 2022Microbiology

Birnaviridae virus factories show features of liquid-liquid phase separation, and are distinct from paracrystalline arrays of virions observed by electron microscopy

V. R. A. P. Reddy, E. A. Campbell, J. Wells, J. Simpson, S. Nazki, P. C. Hawes, A. J. Broadbent

The paper identifies Birnaviridae virus factories as non-membrane-bound structures with liquid-liquid phase separation properties, distinct from paracrystalline virion arrays.

bioRxiv · Nov 16, 2021Microbiology

Transcriptomic analysis reveals that severity of infectious bursal disease in White Leghorn inbred chicken lines is associated with greater bursal inflammation in vivo and more rapid induction of pro-inflammatory responses in primary bursal cells stimulated ex vivo.

A. S. Asfor, S. Nazki, V. R. Reddy, E. Campbell, K. L. Dulwich, E. S. Giotis, M. A. Skinner, A. J. Broadbent

This study compares the transcriptomic responses of inbred chicken lines to IBDV infection, finding that severe disease correlates with enhanced inflammation and faster pro-inflammatory gene induction in bursal cells.

bioRxiv · Mar 18, 2021Microbiology

The stronger downregulation of in vitro and in vivo innate antiviral responses by a very virulent strain of infectious bursal disease virus (IBDV), compared to a classical strain, is mediated, in part, by the VP4 protein.

K. L. Dulwich, A. S. S. Asfor, A. G. Gray, E. S. Giotis, M. A. Skinner, A. J. Broadbent

This study compares the innate antiviral responses of two IBDV strains, showing that the very virulent UK661 strain suppresses IFN and proinflammatory gene expression more than the classical F52/70 strain, mediated in part by the VP4 protein.

bioRxiv · Dec 17, 2019Microbiology

Discrete virus factories form in the cytoplasm of cells co-infected with two strains of the segmented dsRNA virus, infectious bursal disease virus (IBDV), that subsequently coalesce

E. A. Campbell, A. G. Gray, J. Wells, J. Simpson, P. C. Hawes, A. J. Broadbent

This study tracks virus factory dynamics during co-infection of two IBDV strains, showing VFs coalesce later in infection, potentially enabling reassortment.

bioRxiv · Dec 10, 2019 · PreprintMicrobiology

Differential gene expression in chicken primary B cells infected ex vivo with attenuated and very virulent strains of infectious bursal disease virus (IBDV)

K. L. Dulwich, E. S. Giotis, A. Gray, V. Nair, M. A. Skinner, A. J. Broadbent

This study compares gene expression in chicken B cells infected with attenuated and very virulent IBDV strains to identify differences in immune response and virulence factors.

bioRxiv · Aug 24, 2017Microbiology