M. A. Skinner

Transcriptomic analysis reveals that severity of infectious bursal disease in White Leghorn inbred chicken lines is associated with greater bursal inflammation in vivo and more rapid induction of pro-inflammatory responses in primary bursal cells stimulated ex vivo.

This study compares the transcriptomic responses of inbred chicken lines to IBDV infection, finding that severe disease correlates with enhanced inflammation and faster pro-inflammatory gene induction in bursal cells.

Modulation of early host innate immune response by a Fowlpox virus (FWPV) lateral body protein

This study identifies FPV184 as a Fowlpox virus protein that suppresses host IFN responses by inhibiting promoter activation and localizing to viral lateral bodies.

Chicken cGAS senses fowlpox virus infection and regulates macrophage effector function

This study shows that chicken cGAS detects fowlpox virus DNA, triggering type-I interferon production and regulating macrophage effector functions like MHC-II expression.

The stronger downregulation of in vitro and in vivo innate antiviral responses by a very virulent strain of infectious bursal disease virus (IBDV), compared to a classical strain, is mediated, in part, by the VP4 protein.

This study compares the innate antiviral responses of two IBDV strains, showing that the very virulent UK661 strain suppresses IFN and proinflammatory gene expression more than the classical F52/70 strain, mediated in part by the VP4 protein.

The MHC class-II HLA-DR receptor mediates bat influenza A-like H17N10 virus entry into mammalian cells

This study identifies HLA-DR as a receptor for bat influenza A-like H17N10 virus entry into mammalian cells, revealing a novel mechanism distinct from classical influenza A viruses.

Differential gene expression in chicken primary B cells infected ex vivo with attenuated and very virulent strains of infectious bursal disease virus (IBDV)

This study compares gene expression in chicken B cells infected with attenuated and very virulent IBDV strains to identify differences in immune response and virulence factors.