Impact of glycoengineering and immunogenicity on the anti-cancer activity of a plant-made lectin-Fc fusion protein
M. Dent, K. L. Mayer, N. Verjan Garcia, H. Guo, H. Kajiura, K. Fujiyama, N. Matoba
This study shows that glycoengineering AvFc to remove plant glycans enhances its anti-cancer activity by improving Fc receptor binding and ADCC, while being unaffected by anti-drug antibodies.
bioRxiv · May 31, 2022 · PreprintCancer Biology