Impact of glycoengineering and immunogenicity on the anti-cancer activity of a plant-made lectin-Fc fusion protein
M. Dent, K. L. Mayer, N. Verjan Garcia…·N. Matoba
This study shows that glycoengineering AvFc to remove plant glycans enhances its anti-cancer activity by improving Fc receptor binding and ADCC, while being unaffected by anti-drug antibodies.