Author

K. Ledwitch

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Biophysics· 1

Signature Assays, Organisms & Methods

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Research Focus:benchmarking· 2 Assay:protein structure· 2 Approach:statistical model· 2 Approach:deep learning· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

J. Meiler· 2 shared S. Ganguly· 2 shared A. Geanes· 1 shared A. Gulsevin· 1 shared B. Allison· 1 shared B. J. Bender· 1 shared E. N. N. Okwei· 1 shared E. Okwei· 1 shared

Activity by Year

2022-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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2 shared papersBiochemistry

J. Meiler

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Author profile →

2 papers

Recent·Most cited

Rosetta 's Predictive Ability for Low-Affinity Ligand Binding in Fragment-Based Drug Discovery

E. Okwei, S. Smith, B. J. Bender, B. Allison, S. Ganguly, A. Geanes, X. Zhang, K. Ledwitch, J. Meiler

This study evaluates RosettaLigand's ability to predict low-affinity ligand binding in fragment-based drug discovery using NMR data and finds it ranks binders with an AUC of 0.74.

bioRxiv · Oct 18, 2022Biochemistry

First crystal structure of a non-canonical amino acid linked to a paramagnetic lanthanide tag facilitates protein structure determination using NMR-derived restraints

E. N. N. Okwei, S. Ganguly, H. L. Darling, J. M. Harp, A. Gulsevin, I. Coin, H. Mchaourab, K. Ledwitch, G. Kuenze, J. Meiler

The paper presents the first crystal structure of a non-canonical amino acid linked to a paramagnetic lanthanide tag, showing how it improves NMR-derived structural modeling of proteins.

bioRxiv · Apr 10, 2022 · PreprintBiophysics