S. Smith

Synergy between Group 2 capsules and lipopolysaccharide underpins serum resistance in Extra-intestinal Pathogenic Escherichia coli

This study shows that E. coli's serum resistance depends on the synergy between capsule and LPS, with LPS affecting capsule tethering and surface expression.

DNA Calorimetric Force Spectroscopy at Single Base Pair Resolution

The paper uses single-molecule mechanical unzipping experiments and machine learning to measure temperature-dependent DNA energy parameters, including previously unknown heat-capacity changes.

Intrauterine Growth-Restricted Pregnant Rats, from Hypertensive Placental Ischemic Dams Display Preeclamptic-like Symptoms: A New Rodent Model of Preeclampsia

This study establishes a new rodent model of preeclampsia by inducing intrauterine growth restriction in pregnant rats, showing elevated blood pressure and oxidative stress.

Flagella are required to coordinately activate competition and host colonization factors in response to a mechanical signal

This study identifies flagella as mechanosensors in Vibrio fischeri that coordinate activation of competition and host colonization factors in response to viscosity changes.

Mating preferences act independently on individual elements of visual signals in Heliconius butterflies

The paper tests whether male Heliconius butterflies prefer full wing patterns or individual elements, finding no preference difference when elements are removed, suggesting independent function of pattern elements in mating and speciation.

Song distinguishability predicts reproductive isolation between subspecies of the dark-eyed junco

This study examines song differences between dark-eyed junco subspecies and finds that more distinguishable songs correlate with reduced hybridization and greater genetic differentiation.

Multiple E3 ligases control tankyrase stability and function

This study identifies novel E3 ligases that regulate tankyrase stability through ubiquitylation, revealing mechanisms that oppose degradation and may inform cancer therapy.

TERRA R-loops connect and protect sister telomeres in mitosis

This study shows that TERRA R-loops maintain sister telomere cohesion in mitosis, protecting cells from DNA damage and senescence by preventing resolution through tankyrase and C19orf43.

The unexpected loss of the "hunger hormone" ghrelin in true passerines: A game changer in migration physiology

The paper shows that true passerines lost the ghrelin gene but retain its receptor, suggesting a replacement ligand for migratory fat accumulation.

Evidence for microbially-mediated tradeoffs between growth and defense throughout coral evolution

This study shows that microbial symbionts, particularly Endozoicomonas, influence coral growth and disease susceptibility across 425 million years of evolution.

Conserved metabolic regulator ArcA responds to oxygen availability, iron limitation, and cell envelope perturbations during bacteremia

This study identifies ArcA as a conserved metabolic regulator in Gram-negative bacteria during bacteremia, showing its role in adapting to oxygen, iron, and membrane stress.

FRESH™ 3D bioprinted cardiac tissue, a bioengineered platform for in-vitro toxicology and pharmacology

This paper develops FRESH 3D bioprinted cardiac tissues to improve in vitro pharmacology and toxicology screening by mimicking native-like physiological responses to adrenergic agonists.

Wireless Electrical-Molecular Quantum Signalling for Cancer Cell Induced Death

This paper demonstrates wireless electrical-molecular quantum signalling using bio-nanoantennae to induce apoptosis in cancer cells through quantum biological tunnelling.

Species-specific LUBAC-mediated M1 ubiquitination regulates necroptosis by segregating the cellular distribution and fate of activated MLKL

The paper identifies LUBAC-mediated M1 ubiquitination as a species-specific checkpoint regulating necroptosis by controlling MLKL membrane accumulation in human cells and organoids.

Field testing of an enzymatic quorum quencher coating additive to reduce biocorrosion of steel

This study evaluates a lactonase enzyme coating to reduce biocorrosion of steel in marine environments, finding it significantly lowers corrosion tubercles and surface area compared to a biocide control.

Electric Field Responsive Nanotransducers for Glioblastoma

This paper investigates the use of gold, silica oxide, and zinc oxide nanoparticles to enhance the anticancer effects of electric fields on glioblastoma cells.

Rosetta 's Predictive Ability for Low-Affinity Ligand Binding in Fragment-Based Drug Discovery

This study evaluates RosettaLigand's ability to predict low-affinity ligand binding in fragment-based drug discovery using NMR data and finds it ranks binders with an AUC of 0.74.

Stat3 co-operates with mutant Ezh2Y641F to regulate gene expression and limit the anti-tumor immune response in melanoma

This study shows that Ezh2Y641F mutant interacts with Stat3 to alter gene expression and suppress anti-tumor immunity in melanoma.

Defining the Ligand-dependent Interactome of the Sigma 1 Receptor

This study defines the ligand-dependent interactome of the Sigma 1 Receptor using biotinylation and mass spectrometry, revealing novel interactions and functional roles in cholesterol metabolism.

USP22 controls type III interferon signaling and SARS-CoV-2 infection through activation of STING

This study identifies USP22 as a regulator of STING and type III IFN signaling, showing its role in SARS-CoV-2 infection and antiviral defense in human intestinal epithelial cells.

Possible Cross Reactivity of Feline and White-tailed Deer Antibodies Against the SARS-CoV-2 Receptor Binding Domain

The paper reports cross-reactive antibodies against SARS-CoV-2 RBD in pre-pandemic feline and post-pandemic white-tailed deer sera, suggesting potential exposure to SARS-like coronaviruses.

Local accessory gene sharing drives lineage-specific acquisition of antimicrobial resistance in Egyptian Campylobacter spp.

This study analyzes Campylobacter isolates from Egypt to show increased local accessory genome sharing in specific lineages, contributing to higher antimicrobial resistance in C. coli.

SARS-CoV-2 neutralising antibodies in Dogs and Cats in the United Kingdom

This study reports the first large-scale serological survey of SARS-CoV-2 neutralising antibodies in dogs and cats in the UK, finding low prevalence during the second wave of human infections.

Phylodynamic signatures in the emergence of community-associated MRSA

This study uses phylodynamic methods to analyze the emergence and spread of community-associated MRSA lineages globally, identifying common patterns of epidemic growth and transmission.

Systemic and mucosal mobilization of granulocyte subsets during lentivirus infection

This study examines granulocyte subset dynamics in systemic and mucosal tissues during lentivirus infection in rhesus macaques, finding altered frequencies in chronic infection, particularly in gastrointestinal mucosae.

Alveolitis in severe SARS-CoV-2 pneumonia is driven by self-sustaining circuits between infected alveolar macrophages and T cells

The paper identifies a positive feedback loop between SARS-CoV-2-infected alveolar macrophages and T cells in severe COVID-19 patients, driving persistent alveolitis.

The structural dynamics of macropinosome formation and PI3-kinase-mediated sealing revealed by lattice lightsheet microscopy

This study uses lattice lightsheet microscopy to show that PI3K activity is critical for sealing ruffles into macropinosomes, but not for regulating their morphology.

Human antigen-specific memory natural killer cell responses develop against HIV-1 and influenza virus and are dependent on MHC-E restriction

This study shows human NK cells develop antigen-specific memory against HIV-1 and influenza via MHC-E restriction, validated through single-cell cloning and biomarker analysis.

Linking Enzyme Upregulation to Autophagic Failure: A Potential Biomarker for GM1 Gangliosidosis

The paper shows that enzyme upregulation correlates with autophagic failure in GM1 Gangliosidosis, suggesting autophagy impairment as a potential biomarker for disease progression.

TIN2 facilitates TRF1-mediated trans- and cis-interactions on physiologically relevant long telomeric DNA

This study shows TIN2 promotes TRF1-mediated DNA-DNA bridging on telomeres, stabilizing interactions that depend on telomere length and sequence.