K. Leibowitz

p300 KAT regulates SOX10 stability and function in human melanoma

This study identifies p300 KAT as a regulator of SOX10 stability and function in melanoma, showing that inhibiting p300 reduces SOX10 levels and melanoma proliferation and invasion.

The p300 KAT inhibitor, A-485, inhibits melanogenesis and melanin content in human melanocytes

This study shows that the p300 inhibitor A-485 reduces melanin production in human melanocytes by decreasing MITF and DCT expression.