Author

A. Waddell

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Cancer Biology· 2 Immunology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Organism:human· 5 Assay:proteomics· 3 Assay:bulk RNA-seq· 2 Research Focus:cancer & tumor microenvironment· 2 Research Focus:differential expression· 2 Research Focus:host-pathogen & immune response· 2 Organism:mouse· 2

Frequent Co-Authors

A. Shaw· 2 shared H. Ojha· 2 shared M. A. Schumacher· 2 shared M. Muqit· 2 shared M. R. Frey· 2 shared P. Kakade· 2 shared R. Bayliss· 2 shared T. Macartney· 2 shared

Activity by Year

2020-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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2 shared papersBiochemistry

A. Shaw

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

p300 KAT regulates SOX10 stability and function in human melanoma

A. Waddell, N. Grbic, K. Leibowitz, W. A. Wyant, S. Choudhury, K. Park, M. Collard, P. A. Cole, R. M. Alani

This study identifies p300 KAT as a regulator of SOX10 stability and function in melanoma, showing that inhibiting p300 reduces SOX10 levels and melanoma proliferation and invasion.

bioRxiv · Feb 20, 2024Cancer Biology

Regulation of Human PINK1 ubiquitin kinase by Serine167, Serine228 and Cysteine412 phosphorylation

A. Waddell, H. Ojha, S. Agarwal, C. Clarke, A. Terriente-Felix, H. Zhou, P. Kakade, A. Knebel, A. Shaw, R. Gourlay, J. Varghese, R. Soares, R. Toth, T. Macartney, P. Eyers, , M. Muqit

This study identifies phosphorylation sites in hPINK1 that regulate its activation and ubiquitin interaction, revealing a novel inhibitory mechanism involving pCys412.

bioRxiv · Mar 31, 2023 · PreprintBiochemistry

Microbiota epigenetically direct tuft cell differentiation to control type 2 immunity

E. M. Eshleman, T. Rice, C. Potter, A. Waddell, S. Hashimoto-Hill, V. Woo, S. Field, L. Engleman, M. A. Schumacher, M. R. Frey, L. A. Denson, F. D. Finkelman, T. Alenghat

This study shows that butyrate-producing bacteria epigenetically control tuft cell differentiation via HDAC3, influencing type 2 immunity and helminth responses.

bioRxiv · Mar 2, 2023Immunology

Mapping of a N-terminal α-helix domain required for human PINK1 stabilisation, Serine228 autophosphorylation and activation in cells

P. Kakade, H. Ojha, O. Raimi, A. Shaw, A. Waddell, J. Ault, S. Burel, K. Brockmann, A. Kumar, M. Ahanger, E. Krysztofinska, T. Macartney, R. Bayliss, J. C. Fitzgerald, M. Muqit

This study identifies an N-terminal α-helix domain in PINK1 critical for its stabilization, autophosphorylation, and activation, linking mutations in this region to Parkinson's disease.

bioRxiv · Sep 6, 2021Biochemistry

The DAXX-SREBP axis promotes oncogenic lipogenesis and tumorigenesis

I. Mahmud, G. Tian, J. Wang, J. Lewis, A. Waddell, M. L. Lydon, L. Y. Zhao, J.-L. Li, H. T. Purayil, Z. Huo, Y. Daaka, T. J. Garrett, D. Liao

This study identifies the DAXX-SREBP axis as a driver of lipogenesis and tumorigenesis by showing its role in activating lipogenic gene expression and promoting tumor growth.

bioRxiv · Dec 31, 2020 · PreprintCancer Biology

Sprouty2 limits intestinal tuft and goblet cell numbers through GSK3β-mediated restriction of epithelial IL-33.

M. A. Schumacher, J. J. Hsieh, C. Y. Liu, K. L. Appel, A. Waddell, D. Almohazey, K. Katada, J. K. Bernard, E. B. Bucar, S. Gadeock, K. M. Maselli, M. K. Washington, T. C. Grikscheit, D. Warburton, M. J. Rosen, M. R. Frey

This study shows that Sprouty2 restricts intestinal tuft and goblet cell numbers via GSK3β-mediated IL-33 expression, with implications for inflammatory bowel disease.

bioRxiv · Mar 9, 2020Physiology