K. Park

PITPβ promotes COPI vesicle fission through lipid transfer and membrane contact formation

The paper identifies PITPβ's role in COPI vesicle fission by delivering phosphatidylcholine through membrane contacts, revealing a mechanism for lipid transfer in intracellular transport.

Effects of antiretroviral treatment on central and peripheral immune response in mice with EcoHIV infection

This study examines how antiretroviral treatment affects immune responses in the brain and blood of EcoHIV-infected mice, identifying treatment-induced changes in cytokine and chemokine expression.

Discovery of the First-in-class G9a/GLP PROTAC Degrader

This paper discovers a first-in-class PROTAC degrader for G9a/GLP, showing effective degradation and superior anticancer activity compared to existing inhibitors.

A ribosome-associating chaperone mediates GTP-driven vectorial folding of nascent eEF1A

The paper identifies Ypl225w as a chaperone that facilitates GTP-driven co-translational folding of eEF1A by interacting with the ribosome and NAC.

Metabolic Quadrivalency in RSeT Human Embryonic Stem Cells

This study identifies a unique metabolic state in RSeT human embryonic stem cells characterized by quadrivalency, linking it to growth independence from oxygen and resistance to naive reprogramming.

p300 KAT regulates SOX10 stability and function in human melanoma

This study identifies p300 KAT as a regulator of SOX10 stability and function in melanoma, showing that inhibiting p300 reduces SOX10 levels and melanoma proliferation and invasion.

De novo lipid synthesis and polarized prenylation drives cell invasion through basement membrane

The paper shows that de novo lipid synthesis and polarized prenylation are essential for cell invasion through basement membrane in C. elegans anchor cells.

Resistance to Naive and Formative Pluripotency Conversion in RSeT Human Embryonic Stem Cells

This study characterizes a new pluripotent state in RSeT hESCs, showing resistance to naive and formative conversion and distinct transcriptomic and signaling features.

Structural elucidation of how ARF small GTPases induce membrane tubulation for vesicle fission

The paper determines the structure of ARF6 protein lattice on tubulated membranes, revealing its role in vesicle fission and how GAP proteins interact with it.

Operator model for evolutionary dynamics

The paper introduces an operator model to represent evolutionary factors mathematically and demonstrates its application in simulating mutation accumulation under different regimes.

Decoding spatial organization maps and context-specific landscapes of breast cancer and its microenvironment via high-resolution spatial transcriptomic analysis

This study uses high-resolution spatial transcriptomics to analyze breast cancer and its microenvironment, revealing spatially distinct immune cell gradients and transcriptional differences between tumors.

Unveiling the enigma of Brain-resident immune cells

This study identifies distinct brain-resident immune cell populations with unique transcriptional profiles, showing age-related changes and altered interactions in Alzheimer's disease.

Non-coding sequence variation reveals fragility within interleukin 2 feedback circuitry and shapes autoimmune disease risk

The paper shows how non-coding variants affecting IL2RA enhancers alter T cell feedback circuits, leading to opposing autoimmune outcomes in mice.

Melanotransferrin Functions as a Pro-Oncogenic WNT Agonist: A Yin-Yang Relationship in Melanoma with the WNT Antagonist and Metastasis Suppressor, NDRG1

This study identifies MTf as a pro-oncogenic WNT agonist that forms a bidirectional feedback loop with NDRG1, promoting melanoma progression and metastasis.

The C. elegans Anchor Cell Transcriptome: Ribosome Biogenesis Drives Cell Invasion through Basement Membrane

The paper identifies ribosome biogenesis and endomembrane expansion as key drivers of C. elegans anchor cell invasion through basement membrane using transcriptomic and functional analyses.

Cotranslational formation of disulfides guides folding of the SARS CoV-2 receptor binding domain

The paper investigates how disulfide bond formation during translation guides the folding of the SARS-CoV-2 RBD, showing that non-equilibrium mechanisms are required to prevent misfolding.

Baculoviral COVID-19 Delta DNA vaccine cross-protects against SARS-CoV2 variants in K18-ACE2 transgenic mice

This paper develops a baculoviral DNA vaccine targeting the SARS-CoV2 Delta variant, showing 100% survival against Delta and Omicron in mice, compared to 50% survival with the original vaccine.

Q-SHINE: a versatile sensor for glutamine measurement via ligand-induced dimerization

The paper introduces Q-SHINE, a sensor for measuring glutamine levels through ligand-induced dimerization, enabling accurate detection in bio-fluids and living cells.

McaA and McaB control the dynamic positioning of a bacterial magnetic organelle

This study identifies McaA and McaB as proteins controlling magnetosome chain positioning in Magnetospirillum magneticum AMB-1 through membrane curvature recognition and magnetosome localization.

Systematic conformation-to-phenotype mapping via limited deep-sequencing of proteins

The paper develops a method to map protein conformations to phenotypes by systematically analyzing disulfide bonds in proteins.

Bicarbonate Activation of Monomeric Photosystem II-PsbS/Psb27 Complex

The paper shows that a Photosystem II monomer with PsbS and Psb27 subunits is inactive but becomes active when bicarbonate is added, suggesting it is a late-stage intermediate in PSII assembly.

Effect of chronic JUUL aerosol inhalation on inflammatory states of the brain, lung, heart and colon in mice

Chronic JUUL aerosol inhalation in mice alters inflammatory states in brain, lung, heart, and colon, with flavor-dependent effects and potential long-term health risks.

Novel Paju Apodemus Paramyxovirus 1 and 2, Harbored by Apodemus agrarius in The Republic of Korea

This study identifies two novel paramyxoviruses, PAPV-1 and PAPV-2, from Apodemus agrarius rodents in Korea, revealing distinct genome structures and zoonotic potential.

Altering CLC stoichiometry by reducing non-polar side-chains at the dimerization interface

This study shows that non-polar side-chains at the dimerization interface of CLC-ec1 are important for dimer stability, but dimer stoichiometry depends on the solvent environment.

Fibroblasts close a void in free space by a purse-string mechanism

This study shows fibroblasts can close large artificial wounds using a purse-string mechanism similar to epithelial cells, relying on myosin II and adherent junctions.

T cell subset-selective IL2RA enhancers shape autoimmune diabetes risk

This study identifies two enhancers regulating IL2RA expression in T cells, showing how their cell-type-specific effects influence autoimmune diabetes risk.

Sensitivity of radio-photoluminescence glass dosimeters to accumulated doses

This study examines how accumulated doses affect radio-photoluminescence glass dosimeters (RPLGDs) under different photon energies and irradiation conditions.

Transfer of hepatocellular microRNA regulates cytochrome P450 2E1 in renal tubular cells

This study shows that hepatocyte-derived microRNA, particularly miR-122, is transferred to kidney tubular cells and regulates CYP2E1 expression, influencing drug toxicity.

Enhancing generating and collecting efficiency of single particle upconverting luminescence at low-level power excitation

This study improves the luminescence efficiency of upconverting nanoparticles at low excitation power by optimizing dopant concentrations and adding a core-shell structure.

Seasonal Variability and Shared Molecular Signatures of Inactivated Influenza Vaccination in Young and Older Adults

This study identifies shared and seasonal molecular signatures of influenza vaccination in young and older adults, revealing age-specific gene expression patterns linked to antibody responses.