Author

K. Lichauco

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 2 Approach:experimental assay· 2 Organism:mouse· 2 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:gene regulatory network inference· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1

Frequent Co-Authors

H. L. Parrish· 2 shared K. Van Doorslaer· 2 shared M. S. Kuhns· 2 shared M. S. Lee· 2 shared P. J. Tuohy· 2 shared A. Oberst· 1 shared B. P. Daniels· 1 shared C. Kim· 1 shared

Activity by Year

2021-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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2 shared papersImmunology

H. L. Parrish

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3 papers

Recent·Most cited

RIPK3 coordinates RHIM domain-dependent inflammatory transcription in neurons

S. B. Kofman, L. H. Chu, J. M. Ames, S. D. Chavarria, K. Lichauco, B. P. Daniels, A. Oberst

This study shows RIPK3 drives antiviral transcription in neurons during ZIKV infection, while inducing cell death in MEFs, with RHIM domain interactions mediating these context-dependent functions.

bioRxiv · Feb 29, 2024 · PreprintImmunology

The CD4 transmembrane GGXXG and juxtamembrane (C/F)CV+C motifs mediate pMHCII-specific signaling independently of CD4-Lck interactions

M. S. Lee, P. J. Tuohy, C. Y. Kim, P. P. Yost, K. Lichauco, H. L. Parrish, K. Van Doorslaer, M. S. Kuhns

This study shows that CD4's GGXXG and (C/F)CV+C motifs are critical for pMHCII-specific signal amplification without requiring CD4-LCK interactions.

bioRxiv · May 5, 2023Immunology

Enhancing and inhibitory motifs have coevolved to regulate CD4 activity

M. S. Lee, P. J. Tuohy, C. Kim, K. Lichauco, H. L. Parrish, K. Van Doorslaer, M. S. Kuhns

The paper shows that enhancing and inhibitory motifs in CD4 coevolved to regulate pMHCII responses by fine-tuning signal relay across the cell membrane.

bioRxiv · Apr 29, 2021Immunology