A. Oberst

RIPK3 coordinates RHIM domain-dependent inflammatory transcription in neurons

This study shows RIPK3 drives antiviral transcription in neurons during ZIKV infection, while inducing cell death in MEFs, with RHIM domain interactions mediating these context-dependent functions.

Oligodendrocyte-derived IL-33 functions as a microglial survival factor during neuroinvasive flavivirus infection

This paper identifies IL-33 as a critical factor for microglial survival during neuroinvasive flavivirus infection, showing it promotes CNS tolerance without affecting viral clearance or adaptive immunity.

Cellular RNA interacts with MAVS to promote antiviral signaling

The paper shows that cellular RNA interacts with MAVS to scaffold signaling proteins and promote antiviral signaling by facilitating IRF3 phosphorylation.

ZBP1 induces inflammatory signaling via RIPK3 and promotes SARS-CoV-2-induced cytokine expression

This study identifies a ZBP1-RIPK1-RIPK3 pathway that promotes SARS-CoV-2-induced cytokine expression through inflammatory signaling independent of cell death.

Non-canonical autophagy in dendritic cells restricts cross-presentation and anti-tumor immunity

This study shows that Rubicon deficiency in dendritic cells enhances cross-presentation and anti-tumor immunity by increasing phagosome-to-cytosol escape and antigen degradation.

T cells instruct dendritic cells to produce inflammasome independent IL-1β causing systemic inflammation

This study identifies a T cell-instructed, inflammasome-independent pathway of IL-1β production in dendritic cells that drives systemic inflammation in autoimmune diseases.

Activated BAX/BAK enable mitochondrial inner membrane permeabilisation and mtDNA release during cell death

This study shows that BAX/BAK-mediated mitochondrial outer membrane pores widen after MOMP, leading to inner membrane permeabilisation and mtDNA release, which triggers inflammation via cGAS-STING.